FITC标记的Smad核转录共抑制因子抗体
产品名称： FITC标记的Smad核转录共抑制因子抗体
英文名称： Anti-SnoN/FITC
产品编号： HZ-5945R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-SnoN/FITC Conjugated antibody
FITC标记的Smad核转录共抑制因子抗体
| 英文名称 | Anti-SnoN/FITC |
| 中文名称 | FITC标记的Smad核转录共抑制因子抗体 |
| 别 名 | SKI like; Ski related oncogene; Ski related protein; SKIL; SnoA; SNO; SnoA; SnoI; SnoN; SKIL_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 77kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SnoN |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SnoN may have a regulatory role in cell division or differentiation in response to extracellular signals. SnoN acts as a positive mediator of TGF beta induced transcription and cell cycle arrest in lung epithelial cells. The ability of SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity. Function: May have regulatory role in cell division or differentiation in response to extracellular signals. Subunit: Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Tissue Specificity: Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Similarity: Belongs to the SKI family. Database links: UniProtKB/Swiss-Prot: P12757.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Smad核转录共抑制因子(SnoN)是一种拮抗剂，可严格调控转化生长因子-β1/smad(TGF-β1/Smad)信号的活性，从而保证在正常的生理条件下TGF-β1/smad信号输出的稳定性 |
SnO可能在细胞分裂或分化中对细胞外信号的响应起调节作用。SnO可作为TGF-β诱导的肺上皮细胞转录和细胞周期阻滞的正中介体。SnO抑制SMAD蛋白的生长抑制功能的能力是其转化活性所必需的。