FITC标记的缬氨酰-tRNA合成酶抗体
产品名称： FITC标记的缬氨酰-tRNA合成酶抗体
英文名称： Anti-valyl tRNA/FITC
产品编号： HZ-10504R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-valyl tRNA/FITC Conjugated antibody
FITC标记的缬氨酰-tRNA合成酶抗体
| 英文名称 | Anti-valyl tRNA/FITC |
| 中文名称 | FITC标记的缬氨酰-tRNA合成酶抗体 |
| 别 名 | SYVM_HUMAN; Valine--tRNA ligase, mitochondrial; Valyl-tRNA synthetase; ValRS; Valyl-tRNA synthetase-like; valyl tRNA; VARS2; KIAA1885; VARS2L; VARSL. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 合成与降解 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 115kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human vars2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ValRS (valyl-tRNA synthetase), also known as Protein G7a, belongs to the class-I aminoacyl-tRNA synthetase family that includes the related proteins, LeuRS and IleRS. These proteins are large monomeric proteins and play a major role in catalyzing the aminoacylation of tRNA by their cognate amino acid. ValRS joins Val to tRNA(Val) at its synthetic active site. At its CP1 editing active site, ValRS hydrolyzes or deacylates tRNA(Thr) that is incorrectly joined to Val. ValRS forms aggregates with EF-1 (elongation factor 1) and, via this complex, catalyzes the aminoacylation of tRNA and its transfer to EF-1. In addition, ValRS may be regulated by PKC-dependent phosphorylation. Subcellular Location: Mitochondrion (Potential). Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. Database links: Entrez Gene: 7407 Human Entrez Gene: 25009 Rat Omim: 192150 Human SwissProt: P26640 Human SwissProt: Q04462 Rat Unigene: 520026 Human Unigene: 12314 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ValRS(Valyl-tRNA合成酶)又称蛋白G7a，属于I类氨基酰-tRNA合成酶家族，包括相关蛋白LeuRS和IleRS。这些蛋白质是大的单体蛋白质，并且通过它们的同源氨基酸在催化tRNA的氨基酰化中起重要作用。ValRS在其合成活性位点加入VAL-tRNA（VAR）。在其CP1编辑活性位点，ValRS水解或脱*化tRNA(Thr)，该tRNA(Thr)被错误地连接到Val。ValRS与EF-1(伸长因子1)形成聚集体，并通过该复合物催化tRNA的氨基酰化及其向EF-1的转移。此外，ValRS可能受PKC依赖的磷酸化调节。