SOCS1 polyclonal antibody
产品名称： SOCS1 polyclonal antibody
英文名称： SOCS1 polyclonal antibody
产品编号： PAB13191
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SOCS1.
- Immunogen:
- A synthetic peptide corresponding to C-terminus 15 amino acids of human SOCS1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.
Mansell A, Smith R, Doyle SL, Gray P, Fenner JE, Crack PJ, Nicholson SE, Hilton DJ, O'Neill LA, Hertzog PJ.Nat Immunol. 2006 Feb;7(2):148-55. Epub 2006 Jan 15.
- 2.
- The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.Trends Biochem Sci. 2002 May;27(5):235-41.
- 3.
- Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.
O'Shea JJ, Gadina M, Schreiber RD.Cell. 2002 Apr;109 Suppl:S121-31.
- Entrez GeneID:
- 8651
- Protein Accession#:
- CAB92528
- Gene Name:
- SOCS1
- Gene Alias:
- CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3
- Gene Description:
- suppressor of cytokine signaling 1
- Omim ID:
- 603597
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
- Other Designations:
- JAK binding protein,STAT induced SH3 protein 1,Tec-interacting protein 3,cytokine-inducible SH2 protein 1
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