FITC标记的CD351抗体
产品名称： FITC标记的CD351抗体
英文名称： Anti-FCAMR/FITC
产品编号： HZ-16056R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FCAMR/FITC Conjugated antibody
FITC标记的CD351抗体
| 英文名称 | Anti-FCAMR/FITC |
| 中文名称 | FITC标记的CD351抗体 |
| 别 名 | CD351; Fc alpha/mu receptor; Fc receptor, IgA, IgM, high affinity; Fcamr; FCAMR_HUMAN; FKSG87; High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Immunity related factor; Receptor for Fc fragment of IgA and IgM. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FCAMR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc α/μ receptor (FCAMR) functions as a receptor for the Fc fragment of IgA and IgM and mediates their endocytosis. FCAMR is a 532 amino acid protein that is expressed in mesangial cells and is upregulated by IFNG/IFN-γ. It is also expressed in secondary lymphoid organs, such as lymph node and appendix, kidney and intestine, suggesting an important role of the receptor for immunity in these organs. Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. Subcellular Location: Cell membrane. Tissue Specificity: Expressed by mesangial cells. Post-translational modifications: N-glycosylated. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 83953 Human Omim: 605484 Human SwissProt: Q8WWV6 Human Unigene: 145519 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Fc（Ig恒定片段）受体通过从循环中除去Ig包被的抗原复合物，确保宿主免受外来抗原，如微生物和病原体的保护。Fc受体存在于淋巴和髓系衍生物上，它们介导Ig-抗原复合物的内吞作用、通过T细胞抗原呈递在B细胞中产生抗体、细胞毒性和细胞因子及活性氧的释放。Fcα/μ受体（FCAMR）作为IgA和IgM的Fc片段的受体，介导它们的内吞作用。FCAMR是一种在肾小球系膜细胞中表达的532氨基酸蛋白，由IFNG/IFN-γ上调。在淋巴结和阑尾、肾脏和肠等次级淋巴器官中也有表达，提示免疫受体在这些器官中具有重要作用。