TFAM Pre-design Chimera RNAi
产品名称： TFAM Pre-design Chimera RNAi
英文名称： TFAM Pre-design Chimera RNAi
产品编号： H00007019-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 1, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_003201
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 7019
- Gene Name:
- TFAM
- Gene Alias:
- MtTF1,TCF6,TCF6L1,TCF6L2,TCF6L3,mtTFA
- Gene Description:
- transcription factor A, mitochondrial
- Omim ID:
- 600438
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. [provided by RefSeq
- Other Designations:
- OTTHUMP00000019633,Transcription factor 6-like 2 (mitochondrial transcription factor),mitochondrial transcription factor A
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Birth Weight
- Cardiomegaly
- Cardiovascular Diseases
- Cognition
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Insulin Resistance
- Metabolic Syndrome X
- Neoplasms
- Obesity
- Osteoporosis
- Parkinson Disease
- Parkinson disease
- Psychiatric Status Rating Scales