FITC标记的髓样细胞白血病-1抗体
产品名称： FITC标记的髓样细胞白血病-1抗体
英文名称： Anti-MCL1/FITC
产品编号： HZ-1352R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=3ug/Test ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MCL1/FITC Conjugated antibody
FITC标记的髓样细胞白血病-1抗体
| 英文名称 | Anti-MCL1/FITC |
| 中文名称 | FITC标记的髓样细胞白血病-1抗体 |
| 别 名 | myeloid cell leukemia 1; myeloid cell leukemia sequence 1; MCL-1; MCL1L; MCL 1; mcl1/EAT; MGC104264; MGC1839; TM; MCL1S; EAT) Bcl 2 related protein EAT/mcl1; BCL2 related; BCL2L3; EAT; Induced myeloid leukemia cell differentiation protein Mcl 1; myeloid cell leukemia sequence 1; Myeloid cell leukemia sequence 1 BCL2 related; Myeloid cell leukemia sequence 1 isoform 1; OTTHUMP00000032794; OTTHUMP00000032795; TM; bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, Sheep, |
| 产品应用 | Flow-Cyt=3ug/Test ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Mcl-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1. Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. Subunit: Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria. Post-translational modifications: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. Similarity: Belongs to the Bcl-2 family. Database links: Entrez Gene: 4170 Human Entrez Gene: 17210 Mouse Entrez Gene: 60430 Rat Omim: 159552 Human SwissProt: Q07820 Human SwissProt: P97287 Mouse SwissProt: Q9Z1P3 Rat Unigene: 632486 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Mcl1蛋白是bcl-2家族成员,它在调控肿瘤细胞的凋亡、增殖、分化等过程中起一定作用 |
Mcl1是Bcl2家族的抗凋亡成员，最初在佛波酯诱导单核/巨噬细胞分化过程中从ML1人髓系白血病细胞株中分离得到。Mcl1定位于线粒体，与促凋亡Bcl2家族成员相互作用并拮抗，并通过多种细胞毒性刺激抑制细胞凋亡。它参与了分化的规划和伴随的生存能力的维持，而不是增殖。异构体1抑制细胞凋亡，而异构体2促进细胞凋亡。佛波酯诱导髓系白血病细胞系ML1向单核/巨噬细胞分化早期表达增加。