FITC标记的β淀粉样前体蛋白裂解酶2抗体
产品名称： FITC标记的β淀粉样前体蛋白裂解酶2抗体
英文名称： Anti-BACE2/FITC
产品编号： HZ-10494R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-BACE2/FITC Conjugated antibody
FITC标记的β淀粉样前体蛋白裂解酶2抗体
| 英文名称 | Anti-BACE2/FITC |
| 中文名称 | FITC标记的β淀粉样前体蛋白裂解酶2抗体 |
| 别 名 | ALP 56; ALP-56; ALP56; ALP56; Asp 1; ASP1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1; Aspartyl protease 1; BACE 2; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Down region aspartic protease; Downs Syndrome Region Aspartic Protease; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin1; Memapsin-1; Membrane associated aspartic protease 1; Membrane-associated aspartic protease 1; Theta-secretase. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BACE2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Subunit: Monomer. Interacts ith RTN3 and RTN4. Subcellular Location: Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface. Tissue Specificity: Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. Post-translational modifications: Undergoes autoproteolytic cleavage. Glycosylated. Similarity: Belongs to the peptidase A1 family. Database links: Entrez Gene: 25825 Human Entrez Gene: 56175 Mouse Entrez Gene: 288227 Rat Omim: 605668 Human SwissProt: Q9Y5Z0 Human SwissProt: Q9JL18 Mouse SwissProt: Q6IE75 Rat Unigene: 529408 Human Unigene: 97885 Mouse Unigene: 38581 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
淀粉样β肽的脑沉积是阿尔茨海默病的早期和关键特征，是唐氏综合征的常见并发症。淀粉样β肽是由淀粉样前体蛋白经2种蛋白酶水解裂解而产生的，其中一种是由该基因编码的蛋白质。这个基因定位到21号染色体的“临界区”。编码蛋白是肽酶A1蛋白家族的成员，是I型整合膜糖蛋白和天冬氨酸蛋白酶。已经描述了三种编码不同亚型的转录变体。[ RefSeq，JUL 2008 ]提供。