FITC标记的肌动蛋白结合蛋白Fascin3抗体
产品名称： FITC标记的肌动蛋白结合蛋白Fascin3抗体
英文名称： Anti-Fascin-3/FITC
产品编号： HZ-11285R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Fascin-3/FITC Conjugated antibody
FITC标记的肌动蛋白结合蛋白Fascin3抗体
| 产品编号 | bs-11285R-FITC |
| 英文名称 | Anti-Fascin-3/FITC |
| 中文名称 | FITC标记的肌动蛋白结合蛋白Fascin3抗体 |
| 别 名 | Fascin (testis); Fascin 3; Fascin homolog 3 actin bundling protein testicular (Strongylocentrotus purpuratus) ; Fascin homolog 3 actin bundling protein testicular; Fascin3; FSCN 3; FSCN3; MGC94950; Testis fascin; FSCN3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Fascin-3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cell adhesion to extracellular matrix is an important physiological stimulus for organization of the Actin-based cytoskeleton. Adhesion to the matrix glycoprotein Thrombospondin 1 triggers the sustained formation of F-Actin microspikes that contain the Actin-bundling protein Fascin. These structures are also implicated in cell migration, which may be an important function of Thrombospondin 1 in tissue remodelling and wound repair. Fascin bundles Actin microfilaments within dynamic cellular structures such as microspikes, stress fibers and membrane ruffles. Fascin could serve as a prognostic factor for abnormal ovarian epithelial pathology and could be a novel target for the treatment of ovarian cancer. Fascin, an Actin-bundling protein, identifies dendritic cells in the blood and in tissues. Function: Acts as an actin bundling protein (By similarity). Subcellular Location: Cytoplasm, cytoskeleton (By similarity). Tissue Specificity: Expressed in testis. Similarity: Belongs to the fascin family. Database links: Entrez Gene: 29999 Human Entrez Gene: 56223 Mouse SwissProt: Q9NQT6 Human SwissProt: Q9QXW4 Mouse Unigene: 712692 Human Unigene: 31708 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞粘附于细胞外基质是肌动蛋白基细胞骨架组织的重要生理刺激。基质糖蛋白凝血酶敏感蛋白-1的粘附触发了含有肌动蛋白集束蛋白FasCin的F-肌动蛋白微棘的持续形成。这些结构也与细胞迁移有关，这可能是凝血酶敏感蛋白1在组织重塑和创伤修复中的重要功能。FasCin束在动态细胞结构中的肌动蛋白微丝，如微尖峰、应力纤维和膜皱褶。FasCIN可作为卵巢上皮性病变的预后因素，有望成为卵巢癌治疗的新靶点。肌动蛋白结合蛋白Fascin在血液和组织中鉴定树突状细胞。