MDM2 Pre-design Chimera RNAi
产品名称： MDM2 Pre-design Chimera RNAi
英文名称： MDM2 Pre-design Chimera RNAi
产品编号： H00004193-R06
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) (MDM2), transcript variant MDM2e, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_006882
- Target Region:
- Coding sequence
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 4193
- Gene Name:
- MDM2
- Gene Alias:
- HDMX,MGC71221,hdm2
- Gene Description:
- Mdm2 p53 binding protein homolog (mouse)
- Omim ID:
- 164785
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq
- Other Designations:
- Mdm2, transformed 3T3 cell double minute 2, p53 binding protein,double minute 2, human homolog of; p53-binding protein,mouse double minute 2 homolog,p53-binding protein MDM2,ubiquitin-protein ligase E3 Mdm2
- Related Disease
- Abortion, Missed
- Abortion, Spontaneous
- Acquired Hyperostosis Syndrome
- Acute Disease
- Adenocarcinoma
- Anoxia
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Brain Neoplasms
- Breast cancer
- Breast Diseases
- Breast Neoplasms
- Carcinoma
- Carcinoma, Basal Cell
- Carcinoma, Hepatocellular
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung