PIK3CB Pre-design Chimera RNAi
产品名称： PIK3CB Pre-design Chimera RNAi
英文名称： PIK3CB Pre-design Chimera RNAi
产品编号： H00005291-R02
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens phosphoinositide-3-kinase, catalytic, beta polypeptide (PIK3CB), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_006219
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 5291
- Gene Name:
- PIK3CB
- Gene Alias:
- DKFZp779K1237,MGC133043,PI3K,PI3KCB,PI3Kbeta,PIK3C1,p110-BETA
- Gene Description:
- phosphoinositide-3-kinase, catalytic, beta polypeptide
- Omim ID:
- 602925
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM
- Other Designations:
- PI3-kinase p110 subunit beta,PtdIns-3-kinase p110,phosphatidylinositol 3-kinase, catalytic, beta polypeptide
- Interactome
- Gene Pathway
- Acute myeloid leukemia
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Glioma
- Inositol phosphate metabolism
- Insulin signaling pathway
- Jak-STAT signaling pathway
- Leukocyte transendothelial migration
- Melanoma
- mTOR signaling pathway
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Small cell lung cancer
- T cell receptor signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Related Disease
- Adenocarcinoma
- Barrett Esophagus
- Breast cancer
- Breast Neoplasms
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Drug Toxicity
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Glucose Intolerance
- Hepatitis C
- HIV Infections
- Hypercholesterolemia
- Insulin Resistance
- Obesity
- Obesity
- Psychiatric Status Rating Scales