FITC标记的突触富含脯氨酸膜蛋白7抗体
产品名称： FITC标记的突触富含脯氨酸膜蛋白7抗体
英文名称： Anti-PRR7/FITC
产品编号： HZ-12104R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PRR7/FITC Conjugated antibody
FITC标记的突触富含脯氨酸膜蛋白7抗体
| 英文名称 | Anti-PRR7/FITC |
| 中文名称 | FITC标记的突触富含脯氨酸膜蛋白7抗体 |
| 别 名 | Proline rich protein 7; Proline-rich protein 7; Prr7; PRR7_HUMAN; Synaptic proline rich membrane protein; Synaptic proline-rich membrane protein; transmembrane adaptor protein 3; TRAP3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 通道蛋白 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PRR7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PRR7 (proline rich 7), also known as Synaptic proline-rich membrane protein, is a 269 amino acid protein expressed in postsynaptic density (PSD) of the forebrain, especially in hippocampus. The proline rich sequence for which the protein is named is characteristic of a region that is involved in protein-protein interactions, acting as a ligand for SH3, WW and EVH1 domains. As a single-pass type III membrane protein, evidence shows that PRR7 forms a postsynaptic membrane complex with PSD-95 and NMDAz1, suggesting its possible function in the modulation of neural activities. The expression pattern in brain also suggests that PRR7 is essential for synaptic formation or maturation, specifically in the cerebrum. Two isoforms of PRR7 exist as a result of an alternative splicing event. Subcellular Location: Membrane. Cell junction > synapse > postsynaptic cell membrane. Enriched in post-synaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Database links: Entrez Gene: 80758 Human Entrez Gene: 432763 Mouse Entrez Gene: 498704 Rat SwissProt: Q8TB68 Human SwissProt: Q3V0I2 Mouse SwissProt: P0C6T3 Rat Unigene: 534492 Human Unigene: 315457 Mouse Unigene: 162185 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PRR7(proline.7)又称突触富脯氨酸膜蛋白，是一种269个氨基酸，在前脑突触后密度(PSD)中表达，尤其在海马中。该蛋白质命名的富含脯氨酸的序列具有参与蛋白质-蛋白质相互作用的区域的特征，其作为SH3、WW和EVH1结构域的配体。PRR7作为单程III型膜蛋白，与PSD-95和NMDAz1形成突触后膜复合物，提示其在神经活动的调节中可能起作用。脑内的表达模式还表明，PRR7对于突触的形成或成熟是必不可少的，特别是在大脑中。PRR7的两种异构体作为选择性剪接事件的结果而存在。