FITC标记的PRDM锌指转录因子PRDM16抗体
产品名称： FITC标记的PRDM锌指转录因子PRDM16抗体
英文名称： Anti-PRDM16/FITC
产品编号： HZ-19986R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PRDM16/FITC Conjugated antibody
FITC标记的PRDM锌指转录因子PRDM16抗体
| 英文名称 | Anti-PRDM16/FITC |
| 中文名称 | FITC标记的PRDM锌指转录因子PRDM16抗体 |
| 别 名 | CMD1LL; KIAA1675; LVNC8; MDS1/EVI1 like gene 1; MDS1/EVI1-like gene 1; MEL1; PFM 13; PFM13; PR domain containing 16; PR domain containing protein 16; PR domain zinc finger protein 16; PR domain-containing protein 16; PRD16_HUMAN; Prdm16; Transcription factor MEL 1; Transcription factor MEL1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 转录调节因子 t-淋巴细胞 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 140kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PRDM16 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Function: Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation. Subcellular Location: Nucleus. Tissue Specificity: Expressed in uterus and kidney. DISEASE: Note=A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Similarity: Contains 10 C2H2-type zinc fingers. Contains 1 SET domain. Database links: Entrez Gene: 63976 Human Entrez Gene: 70673 Mouse Entrez Gene: 100366024 Rat Omim: 605557 Human SwissProt: Q9HAZ2 Human SwissProt: A2A935 Mouse Unigene: 99500 Human Unigene: 257785 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
互易位t(1;3)(p36;q21)发生在骨髓增生异常综合征(MDS)和急性髓细胞白血病(AML)的一个亚群中。该基因位于1p36.3断裂点附近，在t(1:3)(p36，q21)阳性MDS/AML中特异表达。由该基因编码的蛋白质是锌指转录因子，包含N-末端PR结构域。该易位导致该蛋白缺失PR结构域的截短型过表达，这可能在MDS和AML的发病机制中起重要作用。另外，报道了编码不同亚型的剪接转录变体。[ RefSeq，JUL 2008 ]