Recombinant Human VEGF165

细胞因子的作用特点：多效性、重叠性、协同性、拮抗性和双重性。 　　细胞因子研究具有非常重要的理论和实用意义，它有助于阐明分子水平的免疫调节机理，有助于疾病的预防、诊断和治疗，特别是利用基因工程技术生产的重组细胞因子已用于治疗肿瘤、感染、炎症、造血功能障碍等，并收到良好疗效，具有非常广阔的应用前景

｜细胞因子｜细胞培养｜细胞｜生长因子美国公司是全球最著名的重组细胞因子生厂商之一，目前已开发了350种以上的高品质重组细胞因子和相关抗体，依赖其独有的E. Coli高效率表达系统使其产品的质量稳定，价格低，所有产品以冻干形式提供,以方便运输和储存，特别是以小包装的细胞因子广受全球客户的青睐。产品主要包括免疫调节蛋白、白细胞介素、CSFs、生长因子、干扰素、Chemokines 、Adipokines 、TGFß / BMP Proteins、神经因子、FGFs和TNF配体/受体防御因子等。

 血管内皮生长因子（Vascular endothelial growth factor，VEGF）又称血管通透因子（Vascular permeability factor，VPF），是胎儿和成人血管发生和血管生成过程中重要的调控因子。VEGF是特异性作用于内皮细胞的糖基化细胞有丝分裂素，在增强血管的渗透性、诱导血管发生和血管生成及内皮细胞生长、促进细胞迁移、抑制细胞凋亡等方面发挥作用。由于mRNA不同的剪切方式，产生了VEGF121、VEGF145、VEGF165、VEGF183、VEGF189和VEGF206等6种蛋白形式。VEGF165是人类组织中VEGF主要的基因产物，也是VEGF家族中最重要的血管生成调节因子。

Recombinant Human VEGF165

Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis, intestine, tongue, and lung. Recently Maspin received a great deal of attention due to its potential apoptotic role in cancers. Maspin expression predicts a better prognosis for several types of carcinomas including breast, prostate, colon, and oral squamus cell carcinoma. The level of Maspin is also inversely correlated to VEGF-A, an angiogenic factor. Researchers found that Maspin may play its apoptotic role as an endogenous inhibitor of histone deacetylase I (HDAC I). Therefore, Maspin is a potential personalized marker of Non-Small Cell Lung Carcinoma (NSCLC).

Recombinant human Maspin (rhMaspin) produced in E. coli is a single non-glycosylated polypeptide chain containing 375 amino acids. rhMaspin has a molecular mass of 42.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

Recombinant Human VEGF165