FITC标记的磷酸化上皮钙粘附分子抗体
产品名称： FITC标记的磷酸化上皮钙粘附分子抗体
英文名称： Anti-Phospho-E Cadherin (Ser838 + Ser840)/FITC
产品编号： HZ-12886R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Phospho-E Cadherin (Ser838 + Ser840)/FITC Conjugated antibody
FITC标记的磷酸化上皮钙粘附分子抗体
| 英文名称Anti-Phospho-E Cadherin (Ser838 + Ser840)/FITC中文名称FITC标记的磷酸化上皮钙粘附分子抗体别 名E Cadherin (phospho S838 + S840); p-E Cadherin (phospho S838 + S840); E-cadherin; anion exchanger protein 3; Arc 1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 234; CD324; CD324 antigen; CDH1; CDHE; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin; CADH1_HUMAN. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 产品类型磷酸化抗体 研究领域细胞生物 发育生物学 信号转导 干细胞 细胞粘附分子 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, 产品应用ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量80kDa细胞定位细胞膜 性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated Synthesised phosphopeptide derived from human E Cadherin around the phosphorylation site of Ser838 + Ser840亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6), R-cadherin, B-cadherin, E/P cadherin and cadherin-5. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as ∫-catenin, to regulate cadherin function. Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. Subunit: Homodimer. Subcellular Location: Cell junction. Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Non-neural epithelial tissues. Post-translational modifications: During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disaaaembly of adherens junctions. DISEASE: Defects in CDH1 are the cause of hereditary diffuse gastric cancer (HDGC) . An autosomal dominant cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. Note=Heterozygous germline mutations CDH1 are responsible for familial cases of diffuse gastric cancer. Somatic mutations in the has also been found in patients with sporadic diffuse gastric cancer and lobular breast cancer. Similarity: Contains 5 cadherin domains. Database links: Entrez Gene: 999 Human Omim: 192090 Human SwissProt: P12830 Human Unigene: 461086 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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钙粘附素包括钙依赖性粘附分子家族，其功能是介导对维持组织结构和形态发生至关重要的细胞-细胞结合。该粘附蛋白家族的成员包括大鼠钙粘附蛋白K（及其人类同源物钙粘附蛋白6）、R-钙粘附蛋白、B-钙粘附蛋白、E/P钙粘附蛋白和钙粘附蛋白5。经典的钙粘蛋白，E-，N-和P-钙粘蛋白，由大的细胞外结构域组成，其特征是一系列五个同源NH2末端重复序列。这些钙粘蛋白的最远端被认为负责结合特异性，跨膜结构域和羧基末端胞内结构域。较短的胞内结构域与多种胞质蛋白相互作用，如∫-连环蛋白，调节蛋白的功能。