FITC标记的细胞表面趋化因子受体10抗体
产品名称： FITC标记的细胞表面趋化因子受体10抗体
英文名称： Anti-CCR10/FITC
产品编号： HZ-1710R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-CCR10/FITC Conjugated antibody
FITC标记的细胞表面趋化因子受体10抗体
| 文名称 | Anti-CCR10/FITC |
| 中文名称 | FITC标记的细胞表面趋化因子受体10抗体 |
| 别 名 | C-C chemokine receptor 10; C C chemokine receptor type 10; C C CKR 10; CC chemokine receptor 10; CC CKR 10; CCR 10; CCR-10; CCR10; Chemokine (C C motif) receptor 10; G protein coupled receptor 2; G protein-coupled receptor 2; GPR 2; GPR2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCR-10 (13-45aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008] Function: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 2826 Human Entrez Gene: 12777 Mouse Omim: 600240 Human SwissProt: P46092 Human SwissProt: Q9JL21 Mouse Unigene: 278446 Human Unigene: 103813 Mouse Unigene: 8021 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
趋化因子是一组小的（大约8至14kD），主要是基本的结构相关分子，通过与7跨膜G蛋白偶联受体亚群的相互作用调节各种白细胞的细胞运输。趋化因子在免疫系统的发育、稳态和功能中也发挥基础作用，它们影响中枢神经系统的细胞以及参与血管生成或血管稳定的内皮细胞。根据4个保守的半胱氨酸残基的前两个氨基酸的排列，趋化因子被分成两个主要亚家族，CXC和CC；两个半胱氨酸在CXC趋化因子中由一个氨基酸分离，在CC趋化因子中相邻。CCR10是CCL27的受体(SCYA27；MIM 604833)；CCR10-CCL27相互作用涉及T细胞介导的皮肤炎症(Homey等人，2002[PubMed 11821900])。