FITC标记的蛋白酶体PSMβ3抗体
产品名称： FITC标记的蛋白酶体PSMβ3抗体
英文名称： Anti-Proteasome 20S beta 3/FITC
产品编号： HZ-9357R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Proteasome 20S beta 3/FITC Conjugated antibody
FITC标记的蛋白酶体PSMβ3抗体
| 产品编号 | bs-9357R-FITC |
| 英文名称 | Anti-Proteasome 20S beta 3/FITC |
| 中文名称 | FITC标记的蛋白酶体PSMβ3抗体 |
| 别 名 | 20S Proteasome β3; C10 II; HC10 II; proteasome (prosome, macropain) subunit, beta type 3; Proteasome beta 3 subunit; Proteasome chain 13; proteasome component C10 II; Proteasome theta chain; PSMB3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Proteasome 20S beta 3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring shaped 20S core structure. The core structure is composed of 4 rings of 28 non identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin dependent process in a non lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with HIV-1 TAT protein. Subcellular Location: Cytoplasmic and Nuclear Similarity: Belongs to the peptidase T1B family. Database links: Entrez Gene: 5691 Human Entrez Gene: 26446 Mouse Entrez Gene: 29676 Rat Omim: 602176 Human SwissProt: P33672 Cow SwissProt: P49720 Human SwissProt: Q9R1P1 Mouse SwissProt: P40112 Rat Unigene: 82793 Human Unigene: 94551 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白酶体是具有高度有序的环状20S核心结构的多催化蛋白酶复合物。核心结构由28个不相同亚基的4个环组成，2个环由7个α亚基组成，2个环由7个β亚基组成。蛋白酶体在高浓度的真核细胞中分布，在非溶酶体途径中ATP／泛素依赖的过程中裂解肽。一种修饰的蛋白酶体，免疫蛋白酶体的基本功能，是I类MHC肽的加工。