Anti-PCBP2 Polyclonal Antibody

品牌：solarbio | 货号：K000367P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000367P-50ul	solarbio	50ul	960.00元
K000367P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-PCBP2 Polyclonal Antibody
别名	HNRNPE2;HNRPE2;hnRNP-E2
应用	WB IHC IF
稀释比例	WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反应	Human Mouse Rat
蛋白分子量	39kDa
Gene ID	5094
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human PCBP2
性状	液体
Public Immunogen Range	Recombinant protein of human PCBP2
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	Q15366
克隆类型	Polyclonal Antibody
背景资料	The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.