INPPL1 (N-term) Peptide
产品名称： INPPL1 (N-term) Peptide
英文名称： INPPL1 (N-term) Peptide
产品编号： P3324
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of INPPL1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human INPPL1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading.
Koch A, Mancini A, El Bounkari O, Tamura T.Oncogene. 2005 May 12;24(21):3436-47.
- 2.
- SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor.
Prasad NK, Decker SJ.J Biol Chem. 2005 Apr 1;280(13):13129-36. Epub 2005 Jan 24.
- 3.
- Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
Kaisaki PJ, Delepine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S, Vionnet N, Marion E, Riveline JP, Charpentier G, Schurmans S, Levy JC, Lathrop M, Farrall M, Gauguier D.Diabetes. 2004 Jul;53(7):1900-4.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of INPPL1 polyclonal antibody (Cat # PAB2164) in HepG2 cell line lysate (35 ug/lane). INPPL1 (arrow) was detected using the purified Polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with INPPL1 polyclonal antibody (Cat # PAB2164) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 3636
- Protein Accession#:
- NP_001558;O15357
- Gene Name:
- INPPL1
- Gene Alias:
- SHIP2
- Gene Description:
- inositol polyphosphate phosphatase-like 1
- Omim ID:
- 600829
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq
- Other Designations:
- 51C protein